SUNDAY, JUNE 26

AANS/CNS Continental Breakfast - Thoroughbred Foyer

08:30 am - 10:00 am

Chair: Uzma Samadani, MD, PhD

AANS01-01: Management of OCC-CERV and C1-2 FXS and Dislocations

   Christopher Shaffrey, MD - University of Virginia

AANS01-02: Treatment of the Difficult Thoraco-Lumbar Fractures

   Cati Miller, MD - University of Minnesota

AANS01-03: Spinal Decompression: Should Durotomy be Part of the Decompression?

   Eve Tsai, MD, PhD - University of Ottowa

10:30 am - 12:00 pm 

Chair: Jamie Ullman, MD

AANS02-01: Brain Tissue Oxygenation - What Have We Learned From BOOST2?

   Ramon Diaz Arrastia, MD, PhD - Uniformed Services University

AANS02-02: Severe TBI Guidelines

   Jamie Ullman, MD - Mount Sinai Hospital

AANS02-03: Light Therapy for Moderate TBI

   Rajiv Gupta, MD, PhD - Massachusetts General Hospital

12:00 pm - 01:00 pm

EXHIBITS OPEN / FREE TIME / LUNCH ON YOUR OWN

01:00 pm - 02:30 pm 

Chair: Ann Parr, MD, PhD

AANS03-01: Nerve Transfers for Cervical Spinal Cord Injury

   Wilson Z. Ray, MD – Washington University at St. Louis

AANS03-02: Paired Magnetic and Electrical Stimulation for Cervical SCI

   Noam Harel, MD – Mount Sinai Hospital

AANS03-03: Stem Cells and SCI 

   Ann Parr, MD, PhD - University of Minnesota

03:00 pm - 04:30 pm 

Chair:    Tanvir Choudhri, MD – Mount Sinai Hospital

AANS04-01: Are We Ever Going to Have a TBI Clinical Trial that Succeeds?

   Uzma Samadani, MD, PhD - University of Minnesota

AANS04-02: Return To Work and Play After Concussion/TBI

   Tanvir Choudhri, MD – Mount Sinai Hospital

AANS04-03: Can Technology Save Us? The Biomechanics of Concussion Prevention

   Kristy Arbogast, MD – Children’s Hospital of Philadelphia

WORKSHOPS:

01:00 pm - 04:00 pm

WS01: Human TBI Neuropathology Training Session:
Acute Pathologies with a Focus on Axonal Injury
Heritage Ballroom 1 - FULL

Chair: Patricia Washington, PhD

WS01-01: Neuropathology of Human TBI: Lost in Translation?

   William Stewart, PhD - University of Glasgow

WS01-02: Is it Real or Not? Common Mistakes in Staining and Examining Injury Tissue

   Patricia Washington, PhD - Columbia University

01:00 pm - 04:00 pm

WS02: TBI Preclinical Research Methods
Heritage Ballroom 2

Chair: Kenneth Curley, MD

WS02-01: The WRAIR Projectile Concussive Impact (PCI) Model

   Deborah Shear, PhD – Walter Reed Army Institute of Research

WS02-02: The WRAIR Model of Penetrating Ballistic-Like Brain Injury
   Andrea Mountney, CPT - Walter Reed Army Institute of Research

WS02-03: Blast Physics and Open Field Blast Models (Rodent, Swine)
   Timothy Walilko, PhD - Applied Research Associates, Inc.

WS02-04: Identification of Mild, Moderate and Severe Blast Overpressure Ranges in Experimental Animal Models Subjected to Primary Blast TBI
   Namas Chandra, PhD - New Jersey Institute of Technology

WS02-05: The Controlled Cortical Impact Model: Applications, Considerations for Researchers and Future Directions

   C. Edward Dixon, PhD - University of Pittsburgh

WS02-06: Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development

   Susan Margulies, PhD - University of Pennsylvania

01:00 pm - 03:00 pm

Sponsored by 

03:00 pm - 06:00 pm

WS03: Dissecting Brain Function in Mouse and Human

Chair: Jane Roskams, PhD - The Allen Institute for Brain Science

WS03-01: An Extended Retinotopic Map of Mouse Cortex

   Jun Zhuang, PhD

WS03-02: Mapping Human Brain Development and Lineage Using Embryonic Stem Cells

   Boaz Levi, PhD

WS03-03: Do Regions in the Mouse Default Mode Network Connect via Specific Cell Types?

   Jennifer Whitesell, PhD

WS03-04: No Long-Term Transcriptional Effects of Mild Traumatic Brain Injury Identified in a Well-Characterized Aged Cohort

   Jeremy Miller, PhD

   Terri Gilbert, PhD

CLICK HERE TO REGISTER FOR THE HANDS-ON WORKSHOP

01:00 pm - 04:00 pm

WS04: Implementing Common Data Elements in Clinical
Research Activities
Elkhorn C

Chair: Lyn Jakeman, PhD

WS04-01: Overview of the International SCI Data Sets and CDE Project

   Susan Charlifue, PhD - Craig Hospital

WS04-02: Pediatric SCI Common Data Element (CDE) Recommendations: Updates to the National Institute of Neurological Disorders and Stroke SC

   Mary Jane Mulcahey, PhD - Thomas Jefferson University

WS04-03: Use of SCI Common Data Elements in a Patient Registry

   Vanessa Noonan, PhD - Rick Hansen Institute

01:00 pm - 04:00 pm

WS05: Connecting TBI Animal Models to Human Disease:
Biomedical Relevance
Heritage Ballroom 3

Chair: Ramon Diaz-Arrastia, MD, PhD

WS05-01: Rotational Head Injury in a Gyrencephalic Large Animal Model

   Susan Margulies, PhD – University of Pennsylvania

WS05-02: Closed Head Impact Model of Engineered Rotational Acceleration (CHIMERA): Biomechanics and Pathology

   Cheryl Wellington, PhD – University of British Columbia

WS05-03: Comparative Acute and Chronic Effects of Impact Concussion and Blast Neurotrauma Under Condition of Comparable Head Kinematics

   Lee Goldstein, PhD – Boston University

01:00 pm - 04:00 pm

Sponsored by

WS06: What if the Next Breakthrough in Medicine Isn't on Planet Earth?
Elkhorn D

WS06.01: Kris Kimel - Exomedicine Institute & Kentucky Space LCC

WS06-02: Twyman Clements - Space Tango

WS06-03: Gentry Barnett - Space Tango

WS06-04: Michael Golway - Advanced Technologies

06:30 pm - 07:00 pm

Sponsored by  

07:00 pm - 08:30 pm

Sponsored by 

 MONDAY, JUNE 27

Breakfast / Exhibits Open - Bluegrass & Thoroughbred Foyers

INTS/NNS/AANS/CNS 2018 Committee Meeting - Thoroughbred 5

07:00 am - 08:00 am

08:00 am - 9:15 am

Sponsored by  

Chairs: James Geddes, PhD and Ramona Hicks, PhD

PL01-01: Did I Have a Concussion? Bringing the Best Evidence to Emergency Care Centers

   Gerard Gioia, PhD -  Children's National Medical Center

PL01-02: Making It Feasible To Implement Another Screening Tool In Eds – The Secret Is eHRs

   David Wright, MD - Emory University

PL01-03: What Is the Biological Mechanism of mTBI- I?

   Douglas H. Smith, MD - University of Pennsylvania

PL01-04: What Is the Biological Mechanism of mTBI – II?

   Christopher Giza, MD - UCLA

09:15 am - 10:30 am

Chair: Lisa McKerracher, PhD

PL02-01: Guidelines for the Management of Patients with Spinal Cord Injury: The Use of Methylprednisolone Sodium Succinate

   Michael Fehlings, MD, PhD - University Health Network

PL02-01: Advances in TBI Clinical Trial Design

   Geoff Manley, MD, PhD - University of California, San Francisco

Panelists:

   David  Okonkwo, MD, PhD - UPMC Presbyterian

   Marco Rizzo, MD - Vertex Pharmaceuticals

   Wise Young, MD, PhD - Rutgers University

Coffee Break  & Visit Exhibits- Bluegrass & Thoroughbred Foyers

11:00 am - 12:15 pm

Sponsored by  

DB01: DATA BLITZ
Bluegrass Ballroom  

Chairs: Candace Floyd, PhD and Jim Shaughnessy, KSCHIRT

DB01-01: Brian Edlow - Longitudinal changes in cortical network connectivity after recovery from traumatic coma

DB01-02: Molly Hubbard -Sport Concussion Assessment Tool-3rd Edition: Utility to Diagnose Concussion in General Population

DB01-03: Andrew Bankston - Autophagy regulates the final stages of CNS myelination

DB01-04: Fernando Gomez-Pinilla - Enhancing brain metabolism to restore functional connectivity and plasticity after TBI

DB01-05: Lorre Atlan - Network Analysis of event-related potentials after mild brain injury

DB01-06: Matthew Budde - Double Diffusion Encoding Spectroscopy to Detect Spinal Cord Injury

DB01-07: Mikulas Chavko - N-acetylcysteine Amide Ammeliorates Blast-Induced Changes in Blood-Brain Barrier Integrity and Intracranial Pressure in Rats

DB01-08: Christine MacDonald - Factors Influencing GOS-E Disability Outcome Following Combat Concussive TBI

DB01-09: Jordan Brooks - TEAM-TBI: a monitored multiple interventional TBI research trial

DB01-10: Nai-Kui Liu - Inhibition of cytosolic phospholipid A2 decreases neuronal death after traumatic brain injury

DB01-11: Mabel Terminel - Morphine Undermines Recovery Following SCI via a KOR-mediated Mechanism

DB01-12: Milos Ikonomovic - Therapeutic effects of memantine hydrochloride after brain trauma in humanized amyloid-beta mice

DB01-13: Timothy Meier - Altered resting state functional connectivity in football players is associated with neuroactive kynurenine pathway metabolites

DB01-14: Alpa Trivedi - Molecular pathway analysis of activated neutrophils and their role in long-term cognitive recovery after pediatric brain injury

DB01-15: Rao Gullapalli - Regional brain atrophy following mild TBI is associated with post concussive symptoms at 6 months

DB01-16: Kian Merchant-Borna - Longitudinal tau concentrations in sweat following sport-related concussion: A pilot study

DB01-17: Asla Pitkanen - Analysis of Post-TBI Gene Expression Signature Reveals Tubulins, NFE2L2, NFkB, CD44, and S100A4 as Treatment Targets for TBI

DB01-18: Akinwunmi Oni-Orisan - Network Analysis of Resting State Functional Brain Connectivity in Spinal Cord Injury

DB01-19: Vijayalakshmi Santhakumar - Early increase in neurogenesis after brain injury precipitates long-term decline in neurogenic potential

DB01-20: Andrew Sauerbeck - Characterization of a novel closed head model of diffuse traumatic brain injury

DB01-21: Timothy Van Meter - A Panel of Three Serum Biomarkers Accurately Identifies Brain Injured Patients

DB01-22: Regina Armstrong - Myelin Plasticity Supports Recovery of Nerve Conduction Velocity After Experimental TBI

DB01-23: David Titus - Selective Allosteric Modulation of PDE4D Reverses Chronic Memory Deficits Following Traumatic Brain Injury

DB01-24: Chia-Yi Kuan - Osteopontin as a blood biomarker in traumatic brain injury and hypoxic-ischemic encephalopathy

DB01-25: Lisa McKerracher - Self-delivering RNA to evaluate PTEN as a therapeutic target to promote axon regeneration

12:15 pm - 01:30 pm

WINTR Lunch Session: Discussion of Careers in Science
Thoroughbred Ballroom 4
Chair: Linda Noble, PhD
Ticket Required - Hosted by

Panelists:

Jacqueline Bresnahan, PhD - University of California San Francisco 

Diana Sama, PhD - University of Kentucky

Justin Beller, PhD - Bend Research

Courtney Robertson, MD - Johns Hopkins Medical Institute

FREE TIME / LUNCH ON YOUR OWN

01:30 pm - 02:45 pm

Chairs: David Hovda, PhD and Sarah Ogle, DO

S01-01: Clinical Relevance of TBI and Co-Occurring PTSD

   Thomas McAllister, MD - Indiana University

S01-02: Vulnerability of the Amygdala to TBI

   Asla Pitkanen, MD, PhD - University of Finland

S01-03: Persisting Pathology of the Amygdala After Diffuse TBI

   Theresa Currier-Thomas, PhD - Barrow Neurological Institute

S01-04: Auditory Sensitivity Contributions to Enhanced Fear after Traumatic Brain Injury

   Ann Hoffman, PhD - UCLA

01:30 pm - 02:45 pm

Sponsored by  

Chairs: Alexander Rabchevsky, PhD

S02-01: Cardiovascular Complications Following SCI

   Andrei Krassioukov, MD, PhD - University of British Columbia

S02-02: Autonomic Consequences of Graded Contusion SCI in Adult Rats

   David Magnuson, PhD - University of Louisville

S02-03: Effects of Activity-Based Training on Urinary Tract Function after Spinal Cord Injury

   Charles Hubscher, PhD - University of Louisville

01:30 pm - 02:45 pm

Chair: P. David Adelson, MD

S03-01: Epidemiology/Clinical Management of Pediatric SCI

  Rachel Stanley, MD - Ohio State University

S03-02: Clinical Management of Pediatric SCI

   Nicholas Theodore, MD - Barrow Neurological Institute

 S03-03: Considerations of Clinical Rehabilitation for Pediatric SCI

   Cristina Sadowsky, MD – Kennedy Krieger Institute

02:45 pm - 04:00 pm

Chair: David  Okonkwo, MD, PhD - UPMC Presbyterian

 S04-01: Causes and Consequences of Spreading Depolarizations in Focal Ischemia
   Cenk Ayata, MD - Massachusetts General Hospital

S04-02: Spreading Depolarizations in Animal Models of TBI

   Jason Hinzman, PhD - University of Cincinnati

S04-03: Real-Time Detection of Lesion Development in Acute Brain Injury

   Jed Hartings, PhD - University of Cincinnati

02:45 pm - 04:00 pm

Sponsored by  

Chairs: Warren Alilain, PhD and Michael Lane, PhD

S05-01: Optogenetic Dissection Reveals the Architecture of Brainstem and Spinal Cord Respiratory Circuits

   Jared Cregg, BS - Case Western Reserve University

S05-02: Therapeutic Effect of Muscle Stimulation on Respiratory Function After Cervical SCI

   Tatiana Bezdudnaya, PhD -Drexel University

S05-03: Transplantation-Based Replacement of Astrocyte Glutamate Transporters Following SCI

   Angelo Lepore, PhD - Thomas Jefferson University

S05-04: Neurotrophic Signaling and Functional Recovery After

Cervical SCI

   Carlos Mantilla, PhD - Mayo Clinic

02:45 pm - 04:00 pm

Chair: David Brody, MD

S06-01: Diffusion MRI as a Biomarker in TBI, Correlations, Conclusions, and Caveats

   Matthew Budde, PhD - Medical College of Wisconsin

S06-02: Visualizing Axonal Pathology with MRI Connectomics:

Toward a Multimodal Autopsy for TBI

   Brian Edlow, PhD - MGH/Harvard University

S06-03: Pathology of Acute Traumatic Microbleeds Found on MRI

   Larry Latour, PhD - National Institute of Health

S06-04: Advanced Diffusion MRI-Based Radiological-Pathological Correlations in Chronic Traumatic Encephalopathy

   Laurena Holleran, PhD - Washington University

04:00 pm - 06:00 pm

04:00 pm - 06:00 pm

Wine & Cheese with Exhibitors - Bluegrass & Thoroughbred Foyers

Chinese Neurotrauma Scholar Association (CNSA) Meeting 
Thoroughbred Ballroom 4

07:00 pm - 09:00 pm

 TUESDAY, JUNE 28

Breakfast & Exhibits Open - Bluegrass & Thoroughbred Foyers

07:00 am - 08:00 am

07:00 am - 07:45 am

08:00 am - 09:15 am

Chair: Vance Lemmon, PhD

   Kevin Kit Parker, PhD - Harvard University

PL03-02: Axonal Health: Metabolism Takes Center Stage

   Jeffrey Milbrandt, MD, PhD - Washington University

   Ina Wanner, PhD - UCLA

09:15 am - 10:30 am

Chairs: Alexander Rabchevsky, PhD and Lumy Sawaki, MD, PhD

PL04-01: FES for Postural Stability

   Jennifer French - Neurotech Network

PL04-02: FES for Locomotion

   Susan Harkema, PhD - University of Louisville

PL04-03: Exoskeletons Effectively Promote Overground Locomotion

   Amanda Boxtel - Bridging Bionics

Coffee Break & Visit Exhibits - Bluegrass & Thoroughbred Foyers

11:00 am - 12:15 pm

Chair: Diane Snow, PhD

Keynote Speaker:  Michael Straight, Jockey 

12:15 pm - 01:30 pm

Limited to 150 attendees - Hosted by

Tickets: $15.00 includes lunch - FREE to participate in activity

01:30 pm - 02:45 pm

Chair: Grace Griesbach, PhD

S07-01: Hippocampal Circuitry Dysfunction and Blast TBI

   David Meaney, MD - University of Pennsylvania

S07-02: Role of Neuro-Immune Plasticity in Posttraumatic Epilepsy

    Viji Santhakumar, PhD - Rutgers University

S07-03: Developing New Therapeutics for Chronic Cognitive Dysfunction

   Coleen Atkins, PhD - University of Miami

S07-04: Excitatory/Inhibitory Synaptic Imbalance and Dietary Therapy Following Traumatic Brain Injury

   Akiva Cohen, PhD - University of Pennsylvania

01:30 pm - 02:45 pm

Sponsored by 

Chair: David Magnuson, PhD

S08-01: Locomotor Training: Did the Animal Studies Get it Wrong?

   Ray de Leon, PhD - California State University

S08-02: Exercise after Spinal Cord Injury: More Than Just a Strategy for Rehabilitation

   John Houle, PhD - Drexel University

S08-03: Rehabilitation & Epidural Stimulation Plus Transplantation: Enhanced Activation of Motor Circuitry

   Prithvi Shah, PhD - Stonybrook University

01:30 pm - 02:45 pm

Chair: Geoff Manley, MD, PhD

S09-01: FDA Perspective on Validating Traumatic Brain Injury Biomarkers for Use in Qualification and Medical Product Development

   Allison Kumar, PhD - Center for Devices & Radiological Health

S09-02: Blood-Based TBI Biomarker as Theranostic Tools to Support Drug Development in Animals and Humans

   Kevin Wang, PhD - University of Florida

S09-03: Ted: The Role of Consortia, Data Sharing and Regulatory Science in Catalyzing Innovation for Traumatic Brain Injury

   Diane Stephenson, PhD - Critical Path Institute

S09-04: Use of Pathoanatomic Lesions on Brain MRI as Biomarkers In mTBI Patients

   Pratik Mukherjee, PhD - UCSF

02:45 pm - 04:00 pm

Chair: Katherine Helmick, MS

S10-01: Running Head: Gender and Polytrauma

   Odette Harris, MD - Stanford University

S10-02: Sex Differences in Perinatal Hypoxia Ischemia: Functional Outcomes and Repair

   Jaylyn Waddell, PhD - University of Maryland

S10-03: The Role of Estrogen in Recovery from SCI: Lessons from Rodent and Porcine Models

   Candace Floyd, PhD - University of Alabama at Birmingham

02:45 pm - 04:00 pm

Chair: Sarah Stabenfeldt, PhD 

S11-01: Injectable Hydrogel Enables Local Sustained Delivery to Promote Repair After SCI

   Molly Shoichet, PhD - University of Toronto

S11-02: Magnetically Responsive Nanomaterial Drug Delivery Systems for Encouraging Axon Regeneration

   DiAnna Hynds, PhD - Texas Women's University

S11-03: Probing Neural Cells with Carbon Nanotubes: Implications for Translational Medicine

   Vladimir Parpura, MD, PhD - University of Alabama at Birmingham

02:45 pm - 04:00 pm

S12: The Effect of Age on Trauma-Induced Neuroinflammation
Heritage Ballroom 3

Chairs: John Gensel, PhD and Jonathan Godbout, PhD

S12-01: Neuroinflammation and Pediatric TBI

    Michelle Schober, MD - University of Utah

S12-02: Effect of Alzheimer Pathology on Trauma-Induced Neuroinflammation and Cognitive Impairment

   Adam Bachstetter, PhD – University of Kentucky

S12-03: Microglia/Macrophage Form and Function in the Aged TBI Brain

   David Loane, PhD - University of Maryland

Coffee Break  & Visit Exhibits - Bluegrass & Thoroughbred Foyers

04:00 pm - 06:00 pm

Wine & Cheese with Exhibitors - Thoroughbred & Bluegrass Foyers

07:00 pm - 11:00 pm

 WEDNESDAY, JUNE 29

07:00 am - 08:00 am

08:00 am - 09:15 am

Chair: Xiao-Ming Xu, PhD

PL05-01: Influence of Cervical Propriospinal Interneurons in Recovery of Forelimb Function after Spinal Cord Injury

   George Smith, PhD - Temple University

PL05-02: Intrinsic Barriers to Regeneration Following SCI

   Zhigang He, PhD - Harvard Medical School

PL05-03: Genetic Interventions to Promote Axon Regeneration in the Injured Spinal Cord

   Murray Blackmore, PhD - Marquette University

PL05-04: Systemic PTEN Antagonist Peptides Promoted Axon Regeneration and Functional Recovery after CNS Injury

   Shuxin Li, PhD - Temple University

09:15 am - 10:30 am

Chair: Zhifeng Kou, PhD

PL06-01: Susceptibility Weighted Imaging and Mapping in Traumatic Brain Injury

   E. Mark Haacke, PhD - Wayne State University

PL06-02: Differentiation and Quantification of Neuroinflammation and Axonal Damage Using Diffusion MRI

   Victor Song, PhD - Washington University

PL06-03: The State of Molecular Imaging Epigenetics and its Potential in Neurotrauma

   Juri Gelovani, MD, PhD - Wayne State University

10:30 am - 11:00 am

11:00 am - 12:15 pm

Chair: Diana Cummings, PhD - NIH/NINDS

PL07-01: FITBIR’s Role in Big Data

   Patrick Bellgowan, PhD - NIH/NINDS
 

PL07-02: Using Preclinical CDEs and Data Sharing in FITBIR for Injury Model Comparisons

   Douglas H. Smith, MD - University of Pennsylvania
 

PL07-03: What is ENIGMA? Discoveries from 30,000 Brain Scans and Genomes Worldwide

   Elizabeth Wilde, PhD - Baylor College of Medicine
 

PL07-04: Small-Data to Big-Data: Harnessing Large-Scale Data Sharing for Preclinical SCI and TBI Discovery, Replication and Translation

   Adam Ferguson, PhD - UCSF

FREE TIME / LUNCH ON YOUR OWN - Poster Removal

UK Wildcats Facility Tour

FREE - Ticket Required

01:30 pm - 02:45 pm

Chair: Jonathan Lifshitz, PhD

PL08-01: Ethics of Cannabis Treatment in Clinical and Experimental Neurotrauma

   Jason Scott Robert, PhD - Arizona State University

PL08-02: Neuroimaging Reveals Preservation of Brain Morphology After Dietary Omega-3 Fatty Acids

   Andre Obenaus, PhD - Loma Linda University

PL08-03: The Dynamic Relationship Between Sleep and Traumatic Brain Injury

   Christian Baumann, PhD - Zurich University Hospital

03:00 pm - 04:30 pm

Sponsored by

04:30 pm - 04:45 pm

04:45 pm - 05:45 pm